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Published in French in Tropical Dental Journal Volume 25 - March 2002 pages 5-10
Article Open access
Authors : A. KAMAGATE, D. KONE, N.T. COULIBALY, E. BROU, M. SIXOU - Ivory Coast
La Chlorhexidine est un agent antibactérien de la famille des bisbiguanides. Elle est la molécule la plus efficace parmi les antiseptiques à usage buccal. En raison de son utilisation de plus en plus fréquente dans la lutte antibactérienne, nous avons établi un protocole afin d'évaluer la résistance des bactéries de la flore sous-gingivale à son action. Nous avons déterminé la concentration minimale inhibitrice des différentes espèces bactériennes étudiées et, à partir de cette concentration, nous avons augmenté progressivement la concentration en raison de 5 µg/ml, pour créer une pression de sélection. Les résultats indiquent que les bactéries peuvent subir des modifications structurales et/ou biochimiques pour s'adapter à des concentrations plus importantes.
Chlorhexidine is an antibacterial agent of the bisguanide family. It’s the most effectual molecule of all antiseptics for oral use. Because of its so frequent use, we have elaborated a protocol in order to estimate the resistance of the sub-gingival flora bacteria to its actions. We have determined the minimal inhibitory concentration of the different observed bacteria species and, have from that stage, progressively increased the concentration at a rate of 5μg/ml. The obtained results show that the bacteria can undergo structural and/or biochemical alterations to adapt to more significant concentrations.
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